About Us

A leading clinical-stage biotechnology company focused on the design and development of first-in-class anti-infectives for difficult-to-treat, medically unmet diseases.


We are in the midst of a worsening global antimicrobials resistance (AMR) crisis. There is an urgent need for new classes of antibacterial, antifungal and other antimicrobial treatments to address range of challenging infectious diseases that can no longer be resolved with existing drugs.  NovaBiotics is a leading innovator in the anti-infectives space and we are designing and developing new medicines that are potential solutions not only to the AMR crisis, but also for complex diseases with an infectious component such as the respiratory infections associated with cystic fibrosis (CF).

NovaBiotics was founded by our CEO, Dr. Deborah O’Neil in 2004 and operates from sites in Aberdeen, UK  (R&D headquarters), Dublin, Ireland and Boston (MA), U.S. The Company has a successful track record of invention to clinic of its portfolio of therapeutic candidates. These first in class antimicrobials have been developed from our two proprietary technology platforms which are underpinned by an extensive, wholly owned intellectual property estate.

Clinical Stage Products


NM002 (Nylexa®) and NM001 (Lynovex®) are therapy candidates that have been generated from NovaBiotics’ aminothiol technology platform.  NM002 (Nylexa®) ‘supercharges’ the activity of existing antibiotics to which bacteria are resistant or poor to respond.  We are developing Nylexa for the secondary bacterial pneumonia associated with as many as 50% of COVID-19 infections. For further details see Nylexa.  Lynovex in oral and inhaled form are novel, highly differentiated therapies for the treatment of cystic fibrosis-associated lung disease for all CF genotypes (it is not a mutation-specific intervention).

NP213 (Novexatin®) is a step change in the treatment of nail fungus (onychomycosis) and has been derived from the Company’s propriety antimicrobial peptide platform . Based on the results of studies to date, Novexatin is the first topical agent with the potential to resolve infection and deliver rapid cosmetic benefits with very short duration of treatment vs. 48 weeks for currently available topical treatments.


Preclinical Candidates and Pipeline


NovaBiotics is developing a robust pipeline of antifungal and antibacterial candidates from both its aminothiol and peptide platforms including NP339 and NP432 from its proprietary antimicrobial peptide technology platform.

A novel Approach to Antimicrobial Drug Development



Rational drug design and ‘smart immunology’ are the basis of our unique design of novel antimicrobial therapies. We have engineered our platforms and therapy candidates on the natural infection fighting agents that are produced by the body’s immune system in response to infection or inflammation. This is a low risk approach because we already know the mechanism of action of our drug candidates.