NP339 for Respiratory Fungal Disease

For respiratory fungal infections.

 

Fungal infections of the airways are an increasing clinical challenge and negatively impact outcomes in a number of patients with complex respiratory disease.

 

NP339 is an antifungal peptide with activity against Aspergillus spp. Scedosporium spp., Exophiala spp. and other pathogens of relevance to respiratory disease and is being developed in inhaled form for chronic and acute treatment of respiratory fungal infections.  The physicochemical properties of NP339 are ideally suited for direct delivery into the lungs and in simulations of respiratory Aspergillus fumigatus infection, we have already demonstrated that inhaled NP339 is effective in killing Aspergillus within lung tissue [see ECCMID poster here].